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Our group is exploring of how cardiogenesis as well as adult heart remodelling regulated.

 

In particular, we focus on the following topics:

 

  1. Exploring the signalling function of β-catenin and canonical WNT in mammalian heart development

 

  1. Understanding of canonical WNT signalling mechanisms: plakoglobin (γ- catenin) as potential transcriptional co-activator

 

  1. Beta catenin signalling function in adult heart remodelling (hypertrophy, regeneration, aging) and heart metabolism regulation

 

  1. Novel signalling function of αE-catenin in heart maturation and remodelling

 

  1. CRISPRa using for cardiomyogenic reprogramming of fibroblasts